Anne de Pisseleu d'Heilly (), Duchess of Étampes, (15081580) was chief mistress of Francis I of France. She became Francis' mistress following his return from captivity in 1526. Anne enriched her family and friends through her courtly influence and after Francis' death was banished from court and temporarily imprisoned in her husband's castle. She would spend her later years ensuring the fortune of her family. Anne died in 1580.
Anne was described as being sprightly, pretty, witty and cultured, "the most beautiful among the learned and the most learned among the beautiful". The liaison received some official recognition when Francis started wearing Anne's colors. Anne was appointed lady-in-waiting to the new queen, Eleanor of Austria, and later became governess to Francis' two daughters. She used her influence with Francis to elevate and enrich her family; her brother, Adrien sieur d'Heilly, was made captain of the Picard legion, her uncle, Antoine Sanguin, being made Bishop of Orléans in 1533 and a cardinal in 1539; her three other brothers were made bishops. In 1534, Francis gave her in marriage to Jean IV de Brosse, whom he created Duke of Étampes.
Despite her capabilities, Anne was of a fickle nature. In 1545, she tried to discredit Admiral d'Annebault, despite him owing his advancement to her. When her intrigues were discouraged by Archbishop Tournon, Anne attempted to bring about his fall on a charge of dishonesty.
The influence of Anne, especially in the last years of Francis' reign, continued to grow. A staunch Protestant, she counseled Francis on toleration for Huguenots. By October 1546, Anne, along with Cardinal du Bellay, was pressuring Francis to break with Rome. Due to her influence Francis was attending more council meetings, and according to an imperial envoy, Anne was "the real president of the king's most private and intimate council".
Basking in her success at bringing peace between Francis and Charles at Crepy in 1544, Anne convinced Francis that his son the Dauphin Henry and Diane de Poitiers were working to reinstate Montmorency at court. Francis, so instructed, banished Diane from court. In response, Henry and his supporters retreated to the chateau of Anet; father and son would not reconcile until 1545.
Anne was still a wealthy woman, having properties in Paris and a capital of 47,615 livres in rentes. By 1554-55 she was maintaining her niece Jossine de Pisseleu's rights to the Lenoncourt succession from the Guise family. In March 1560, she gave 114,000 livres to her niece, Diane de Barbançon, for her marriage to Jean de Rohan, baron de Frontenay. Anne gave 30,000 livres for her nephew Jean d'Heilly's first marriage, and acted as the intermediary for Jean's second marriage, writing to the lady's ward. She continued to be involved in the lives of her nieces and nephews into her later years.
Anne died in 1580.
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